Prepare For Impact: Market Expert Says Biggest Disaster In Crypto Yet To Come
OEIS Financial Fraud Private Investigator:
Veteran crypto trader, Peter Brandt has issued a warning to the broader crypto community, stating that the industry has yet to experience its biggest disaster. Brandt boldly predicts that this catastrophe will be linked to cryptocurrency staking and the people involved in it.
OEIS Financial Fraud Private Investigator: Staking Could Lead To Crypto’s Greatest Disaster
In an X (formerly Twitter) post on May 24, Brandt labeled crypto staking as one of the biggest threats to the digital currency space. According to the analyst, staking could become the harbinger of disaster for the industry, potentially causing the decline of the market’s reputation and leading to financial losses for traders.
For more clarity, staking is a popular practice in the crypto industry that involves locking assets for an extended period to help support the blockchain. This allows token holders to participate as validators of the blockchain and earn staking rewards.
Brandt cautioned that digital currency enthusiasts and traders involved in staking should be careful as it could potentially lead to bankruptcy and loss of fortune. He believes that staking may bring shocking future events that could possibly devastate the space.
In a follow-up post, the trader outlined a progression of events related to staking, highlighting its potential negative impacts on the market.
He disclosed that crypto staking involves owning, borrowing or leveraging an asset such as Solana and Ethereum. These assets are usually lent out to earn possible revenue, often in the form of interest.
As staking becomes more widespread and accepted, it could attract the attention and involvement of Central Banks, government treasuries and other governmental authorities. Brandt reveals that this attention may lead to increased scrutiny and regulation of the staking process by the government.
Consequently, the introduction of new regulations would have a detrimental effect on the crypto space, fundamentally changing the industry or possibly leading to the end of staking.
Total cryptocurrency market cap currently at $2.5 trillion. Chart: TradingView
OEIS Financial Fraud Private Investigator: Crypto Community Up In Arms
Before issuing his controversial statement about crypto staking, Brandt disclosed that his opinions may not be well received by supporters of popular digital assets such as Ethereum and Solana.
True to this prediction, many community members dismissed Brandt’s warning that staking could potentially bring disaster to the crypto space. A crypto member criticized Brandt for his statement, asserting that the crypto trader was uninformed about staking processes and was overstating the impacts of staking by claiming it would result in a “disaster.”
Another crypto member had argued that Brandt’s definition of staking was factually incorrect. He clarified that staking was a process of using coins or tokens to verify and secure the consensus mechanism of a blockchain.
Furthermore, a crypto community member, Tony Edward disclosed that the only risks in staking are associated with Centralized Exchanges (CEX), not with self custody staking.
Featured image from Pexels, chart from TradingView
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WASHINGTON — A Donald Trump supporter who, federal authorities dispute, plotted to execute FBI special agents investigating him on Jan. 6 costs looks to earn been armed with a gun when he grew to become the fourth rioter to breach the U.S. Capitol, prosecutors acknowledged at trial Tuesday.
He and co-defendant Austin Carter plotted “to execute employees of the Federal Bureau of Investigation” in December 2022, months after Kelley’s arrest on Jan. 6 costs, Carter admitted in a plea agreement. Kelley is decided to trot to trial in that case in a federal court docket in Tennessee on Nov. 18, with a pretrial convention scheduled next week, on Nov. 7.
This week, Kelley used to be in federal court docket in Washington, going through an array of costs in connection with his accepted behavior on Jan. 6, 2021: civil dysfunction; obstruction of an first price persevering with; assaulting, resisting, or impeding officers; destruction of executive property; and a vary of misdemeanors.
His defense team didn’t attach forth any witnesses throughout his trial, and Kelley declined to testify.
Kelley, an anti-abortion-rights activist, wore a sweatshirt finding out TCAPP, standing for “The Church At Deliberate Parenthood,” when he stormed the Capitol, in step with the FBI.
Prosecutors supplied evidence Tuesday that Kelley could perchance possibly earn been armed on Jan. 6. If he used to be, he wouldn’t be alone. Conservative media figures and Trump himself earn acknowledged — falsely — that the mob used to be unarmed. Surely, several rioters were armed with guns, which contributed to their penal complex sentences, including two rioters on the spear of the mob that breached a police line come the tip of the stairs on the west aspect of the Capitol. One more professional-Trump rioter, whom NBC News diagnosed as John Emanuel Banuelos, used to be considered on video firing a gun into the air exterior the Capitol that day. He used to be charged with doing so this One year and ordered held earlier than trial.
The gun allegation isn’t central to the costs in opposition to Kelley, however prosecutors offered strong evidence that he used to be no no longer as much as wearing an internal waistband gun holster that is meant to conceal the backside of a weapon in somebody’s pants.
FBI Special Agent Jessi Mann demonstrated how the gun holster works in her testimony Tuesday, the exercise of a prop weapon to teach how the barrel of the weapon would be concealed internal pants and the take care of of the weapon could perchance possibly possibly additionally very correctly be lined up with a sweatshirt love the one Kelley used to be wearing. Whereas prosecutors didn’t inform a clear portray of the take care of of a weapon slipping out from beneath Kelley’s sweatshirt, Mann testified that the weapon’s “printing,” which design its outline, could perchance possibly possibly additionally very correctly be considered in photos of Kelley throughout the assault. The clip on the holster is also considered in photos, grasping onto Kelley’s belt, Mann acknowledged.
Prosecutors also launched a clear shot of the ammunition pack Kelley regarded to be wearing on his left hip, and Mann testified that Kelley used to be noticed to be ultimate-handed; that is how he signed paperwork, and that is the reason the place he at likelihood of wear his weapon, she acknowledged.
Mann also testified Tuesday that Kelley had sold packing containers of ammunition and gas masks within the times leading as much as the assault and that the FBI had seized garments identical to what he wore on Jan. 6 from his place of dwelling throughout a search. On-line, Kelley inclined encrypted email with the take care of “chaos_continues” to develop a few of his purchases, Mann testified.
Kelley, in a gas conceal, on the Capitol on Jan. 6, 2021, in step with the FBI.U.S. District Court
Prosecutorssupplied pretty a few witnesses within the bench trial earlier than U.S. District Make a willpower Colleen Kollar-Kotelly. They include Capitol Police Officer Eugene Goodman, a Shaded man who used to be chased up the stairs come the Senate chamber on Jan. 6 by the overwhelmingly white mob, which integrated contributors bearing Confederate flags.
Kelley used to be on the front of the mob and used to be considered pointing at Goodman factual earlier than the mob went up the stairs, however it indubitably used to be complex to resolve what, if one thing else, he acknowledged to Goodman due to the respirator he used to be wearing, in step with prosecutors. As soon as he made it within the Senate chamber, Mann testified, he snapped no no longer as much as 2 selfies of himself overlooking the dais the place Vice President Mike Pence had been seated factual moments earlier and the table the place the Electoral Faculty ballots were saved earlier than officers dashed them off to security.
All throughout the assault, prosecutors acknowledged, Kelley entreated his essential other to download Mark, an encrypted app, when she asked how things were stepping into Washington and wrote that she didn’t judge the “unsuitable knowledge,” borrowing a Trump phrase.
“The rioters had come for Congress, and they wouldn’t finish till they got the ballots,” Assistant U.S. Felony professional Patrick C. Holvey immediate the think throughout closing arguments Tuesday, adding that somebody wanted to be held accountable for breaching the Capitol for the first time for the reason that British redcoats did in 1814, throughout the War of 1812.
Bigger than 1,500 other folks earn been charged in connection with the Jan. 6 assault on the Capitol, and prosecutors earn secured bigger than 1,100 convictions. Over 600 defendants earn been sentenced to intervals of incarceration ranging from a few days within the aid of bars to 22 years in federal penal complex.
Characterize Credit rating: One Path by Eva Rinaldi / CC by 2.0
Private investigator near me: An ongoing investigation into the balcony fall that ended in Liam Payne’s demise indicates it would possibly per chance simply were suicide.
One Path extensive name Liam Payne died of internal and exterior bleeding besides to a pair of traumas triggered by a fall from a third-floor resort balcony in Buenos Aires, per the Argentinian prosecutor’s location of business. An submit-mortem, the considerable aspects of that are light impending, confirmed the extensive name’s head accidents had been ample to motive his demise.
The investigation stays ongoing, but interviews with 5 witnesses indicated that Payne became as soon as alone on the time of his fall. Substances seized from his resort room indicated alcohol and drug consumption.
Liam Payne died on Wednesday, around 5 PM native time in Argentina. Guests on the Casa Sur resort instructed authorities and the clicking that they heard banging and shouting for hours earlier than Payne’s fall.
A resort receptionist called emergency providers to checklist police of an “aggressive man who will most likely be below the outcomes of gear and alcohol. The resort supervisor said he heard “a loud noise” on the relief of the resort, and when police arrived on the scene, they found a particular person had fallen over the balcony in his room.
“I believed they had been doing constructing — there became as soon as so worthy banging, doors slamming, many of the day. It became as soon as loud, extraordinary,” a guest instructed The Guardian. “Later, I heard the sirens, pondering perchance there became as soon as a fireplace somewhere. And then I heard a genuinely loud cry.”
Payne became as soon as in Buenos Aires for a concert by fellow One Path alumnus Niall Horan earlier within the month, where the bandmates reunited.
One Path became as soon as fashioned on “The X Factor” relief in 2010 after every of its 5 individuals did now not progress within the competition, even though even as a neighborhood they did now now not get it to the finale. Liam Payne became as soon as most productive 16 when he first performed on the indicate.
Payne’s feeble One Path bandmates Horan, Harry Styles, Louis Tomlinson, and Zayn Malik have yet to touch upon his demise. Singer Cheryl Tweedy, with whom Payne had a son in 2017, has also now now not yet commented publicly.
Www.oeisdigitalinvestigator.com: —
Hypoglycemia was only a concern in patients with type 1 diabetes
by Kristen Monaco
,
Senior Staff Writer, MedPage Today
May 22, 2024
Concerns over hypoglycemia risk with an investigational once-weekly insulin product in patients with type 1 diabetes prompted the FDA to call an advisory committee together to weigh in on the matter.
On Friday, the Endocrinologic and Metabolic Drugs Advisory Committee will discuss the long-acting insulin icodec by Novo Nordisk, which is seeking an indication for improving glycemic control in adults with both type 1 or type 2 diabetes.
In the phase IIIa ONWARDS 6 trial, insulin icodec was just as efficacious — but not superior to — once-daily insulin degludec in type 1 diabetes, yielding a comparable reduction in HbA1c by week 26 (-0.47% vs -0.51%). Both insulins were used in combination with three daily mealtime insulin injections.
However, there was a significantly higher estimated rate of severe or clinically significant hypoglycemia with insulin icodec, marked by a blood glucose under 54 mg/dL (19.93 events per patient year vs 10.37 with the once-daily insulin). The highest risk period for hypoglycemia was around the time of its peak glucose-lowering effect on days 2 to 4 after injection.
This will be the main point of debate for the advisory committee, as briefing documents stated that while hypoglycemia is “an expected adverse reaction” with exogenous insulin, insulin icodec in type 1 diabetes patients in this trial showed “excess hypoglycemia … without evidence of any additional glycemic control or other benefit.”
The FDA previously told Novo Nordisk during an end-of-phase II meeting that meeting the prespecified noninferiority margin (HbA1c at 6 months) “would not be sufficient to establish a favorable benefit-risk profile” when taking into consideration the risk of hypoglycemia. At that meeting, the FDA recommended the phase III study include a third arm evaluating insulin icodec dosed twice-weekly and assess the possible need for additional bolus dose adjustments.
Novo Nordisk already proposed a few label suggestions and risk-mitigation strategies for type 1 diabetes patients that will be discussed on Friday. First, it was suggested insulin icodec be limited to type 1 diabetes patients wearing a continuous glucose monitor and those without a history of hypoglycemia unawareness or recurrence. This was the same criteria used in the trial. It also suggested that the labeling restrict use to type 1 diabetes patients whose glycemic variability is less than 36% prior to initiation.
Another proposal was an alternative dose titration strategy for this group, like cutting the bolus insulin dose by around 30% between days 2 to 4 when hypoglycemia risk is highest.
During the meeting, hypoglycemia risk will be weighed against the unmet need for a wider range of insulin options for this patient population.
Currently, all basal insulin products on the market are designed for daily dosing, so the main benefit of this product is the convenience of a once-weekly dosing option. This strategy may also help to combat nonadherence to insulin therapy — a risk factor for hyperglycemia and diabetic ketoacidosis. One recent meta-analysis found that adherence to insulin therapy in adults with type 1 diabetes was fairly low, at around 53%.
ONWARDS 6 was the only trial in the clinical program to include type 1 diabetes patients, as the other five trials only enrolled type 2 diabetes participants. In the ONWARDS 1 trial presented at last year’s American Diabetes Association meeting, there was a significantly greater average reduction in HbA1c with icodec compared with glargine U100 in insulin-naive people with type 2 diabetes. In this patient population, there was a numerically higher rate of clinically significant or severe hypoglycemia: 0.30 events per person-year of exposure with icodec and 0.16 events per person-year of exposure with glargine U100 at week 52.
“Insulin is insulin,” lead investigator Julio Rosenstock, MD, of Velocity Clinical Research at Medical City in Dallas, said at the meeting. “When we use insulin, there always will be hypoglycemia, but we only had less than one event per year.”
In March, the European Medicines Agency’s advisory committee recommended Novo Nordisk’s insulin icodec for approval in both type 2 and type 1 diabetes, though it said that the product “should only be used in patients with type 1 diabetes for which a clear benefit of a once-weekly administration is expected,” given the hypoglycemia concerns.
While the FDA isn’t required to follow its advisory committees’ recommendations, it typically does.
Kristen Monaco is a senior staff writer, focusing on endocrinology, psychiatry, and nephrology news. Based out of the New York City office, she’s worked at the company since 2015.
