Murdered UnitedHealthcare CEO Brian Thompson and His Accomplice Were Residing in Separate Houses Less Than a Mile Apart When He Used to be Shot
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Conversion surgery after active surveillance for low-risk papillary thyroid carcinoma (PTC) led to no clinically meaningful differences in outcomes as compared with immediate surgery, according to a matched cohort study.
Complication rates did not differ significantly between conversion procedures for suspected disease progression and conversion for reasons unrelated to disease progression. The 5-year overall survival rate was 100% after conversion for progressive disease and immediate surgery.
Rates of local, regional, and distant recurrence did not differ significantly between immediate surgery and delayed conversion, nor did 5-year recurrence-free survival (RFS), reported R. Michael Tuttle, MD, of Memorial Sloan Kettering Cancer Center in New York City, and co-authors in JAMA Otolaryngology-Head & Neck Surgery.
“This study provides additional support to previous observations indicating that, among patients with PTC choosing AS [active surveillance], CS [conversion surgery] for suspected disease progression is associated with surgical and subsequent oncologic outcomes that are similar to the outcomes seen among patients undergoing upfront IS [immediate surgery],” the authors wrote. “In addition, the surgical complexity and sequelae of CS due to disease progression were comparable to those of patients without disease progression.”
“Despite the fact that the disease-progression CS group was enriched for those at the highest risk for adverse oncologic outcomes, CS at the time of disease progression was associated with excellent short-term outcomes,” they added. “These findings are consistent with data from Japanese, Korean, and U.S. centers demonstrating that while disease progression is expected to develop in a small percentage of patients during AS, salvage therapy at the time of disease progression provided oncologic outcomes that are equivalent to outcomes expected in patients selected for IS.”
The study’s low rate of conversion for disease progression (39 of 550) may help “correct perceptions and make the case for greater AS adoption,” which remains “disappointingly limited” in clinical practice, according to the authors of an accompanying commentary.
“The broadening definitions of progression … are excellent guardrails for safe conversion,” wrote Allen S. Ho, MD, of Cedars-Sinai Medical Center in Los Angeles, and co-authors. “The findings … are a reminder that progression is not correlated with death, but to surgical intervention shown to be safe. Finally, conversion was not associated with a greater extent of surgery or greater burden of care, as might be predicted from delayed surgery.”
Limited data have accumulated related to outcomes with delayed surgery after active surveillance, most recently the results of a study among 3,222 patients from a single Japanese hospital. Subsequently, 12.2% of the patients had conversion surgery, which was associated with low rates of nodal metastasis and favorable survival.
Tuttle and colleagues sought to contribute additional contemporary data related to conversion surgery following a period of active surveillance. The analysis included 550 patients with low-risk PTC who underwent surgery from January 2004 to December 2022, with a median surveillance duration of 3.6 years. They defined low risk according to previously published criteria.
The authors performed propensity matching to generate a cohort of 39 patients who had immediate surgery from January 1985 to December 2020. They were matched (for age, sex, tumor size, surgical procedure type, and follow-up duration) with the 39 patients who had progression-related conversion surgery after an initial period of active surveillance.
The data showed no meaningful differences (demographic, clinical, surgical) between the 39 patients who had progression-related conversion surgery and the 16 patients who had conversion for other reasons. Complication rates were 43.8% (seven of 16) versus 30.8% (12 of 39). Rates of vocal cord paresis, seroma, hypocalcemia, and wound infection did not differ between the two groups.
Comparison of the progression-related conversion group and the immediate-surgery group showed that tall-cell subtype was more prevalent in the conversion group (33.3% vs 5.1%). Otherwise, no meaningful differences were observed in clinical or surgical characteristics between the two groups.
The 5-year overall survival rate was 100% in both groups over a median postsurgical follow-up time of 40.3 months. Two patients in the disease-progression group had lymph node recurrences following surgery. Both patients were re-treated surgically and remain without evidence of recurrent disease, the authors noted. No patients in either group had local or metastatic recurrence. The 5-year RFS rate was 100% for patients who had immediate surgery and 86% for those who had surgery for disease progression.
Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. He joined MedPage Today in 2007. Follow
Disclosures
The study was supported by the National Institutes of Health, U.S. Department of Defense, Geoffrey Beene Cancer Research Center, Cycle for Survival, Memorial Sloan Kettering Population Science Research Program, Jayme and Peter Flowers Fund, and the Sebastian Nativo Fund.
Tuttle reported no relevant financial disclosures.
The editorialists reported no relevant financial disclosures.
Primary Source
JAMA Otolaryngology-Head & Neck Surgery
Source Reference: Levyn H, et al “Outcomes of conversion surgery for patients with low-risk papillary thyroid carcinoma” JAMA Otolaryngol Head Neck Surg 2024; DOI: 10.1001/jamaoto.2024.1699.
Secondary Source
JAMA Otolaryngology-Head & Neck Surgery
Source Reference: Ho AS, et al “Active surveillance and conversion surgery for low-risk thyroid cancer — The disconnect between literature and practice” JAMA Otolaryngol Head Neck Surg 2024; DOI: 10.1001/jamaoto.2024.1702.
First Photograph voltaic says it is evaluating capability infringement of its patents for its tunnel oxide passivated contact (TOPCon) tech, secured by the acquisition of TetraSun in 2013. The US skinny-film listing voltaic module manufacturer has not named the companies though-provoking or given a timeline for the investigation.
First Photograph voltaic talked about it is investigating capability violations of the patents it owns for TOPCon listing voltaic cell skills.
“First Photograph voltaic secured the US patent and connected world counterparts by its acquisition of TetraSun, Inc. and has initiated an investigation of loads of c-Si listing voltaic manufacturers for capability infringement of its patents,” the corporate talked about in a recount. “The patents encompass issued patents in the USA, Canada, Mexico, China, Malaysia, Vietnam, Japan, and Australia, amongst varied jurisdictions, with validities extending to 2030. It furthermore involves pending patent functions in the European Union and Japan.”
The corporate has not known the aptitude infringers or offered a timeline for the investigation.
“First Photograph voltaic got TetraSun and its intellectual property portfolio in 2013. Forward of its acquisition, the California-essentially essentially essentially based startup had pioneered proprietary cell architecture and manufacturing processes for pudgy-layout crystalline silicon wafers,” First Photograph voltaic furthermore talked about, with out providing extra technical details. “If infringement is learned, we intend to trouble the flexibility of capability infringers to legally have faith, assemble, and sell infringing TOPCon skills by pursuing enforcement, licensing, and/or varied measures to safeguard our rights.”
First Photograph voltaic produced PV modules the utilize of TetraSun skills at its Malaysian manufacturing facility until 2016, ending its manufacturing of crystalline silicon listing voltaic panels.
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Sorrowful administration and placing chums into the simpler echelons of his administration are key causes Mayor Adams is now mired in scandal, critics charged.
“It’s good to well well even have two brothers, a purposeful wife, and a simplest pal, who’re in these positions of being deputy mayors or senior advisers,” talked about John Kaehny, govt director of the lawful govt community Reinvent Albany talked about of Adams.
“They ran out of crimson flags down on the ironmongery store on fable of they had been utilizing them up on this.”
Sorrowful administration and placing chums into the simpler echelons of his administration are key causes Mayor Adams is now mired in scandal, critics charged. Brigitte Stelzer
David Banks’ lady friend, Sheena Wright, landed a job as first deputy mayor, while Adams’ private lady friend, Tracey Collins, has an opulent $221,000 a one year gig as a senior consultant within the city Division of Education.
The appointment of Philip Banks became once in particular concerning, talked about Kaehny, who renowned he retired in 2014 as NYPD chief of division amid a sprawling federal probe into police corruption, the place he became once named an unindicted co-conspirator.
This seemingly put Banks on the authorities’ radar the second he became once tapped for his put up, Kaehny talked about.
“It’s good to well well even have two brothers, a purposeful wife, and a simplest pal, who’re in these positions of being deputy mayors or senior advisers,” talked about John Kaehny of Mayor Adams. Chad Rachman/Original York Post
Kaehny endured to issue that the appointment of Philip Banks became once in particular concerning. AP
NYPD inspector and shut Adams affiliate Tim Pearson, a high aide who has overseen lucrative migrant security contracts, became once one other concerning appointment,in accordance with Kaehny.
“On the very, very initiating, Adams became once in war with the War of Passion Board over Pearson, who became once taking two salaries, [including] one from a on line casino” that became once purchasing for presidency approval to construct bigger its operations, he talked about.
one year
Destination
Advantages
Cost
Disclosed?
2016
India (by strategy of Turkey)
Free crimson meat up to enterprise class for two on round-time out flight from Original York to India
$12,000
No
2017
France, Turkey, and China
Free enterprise class tickets for three on round time out from Original York to France, Turkey, and China; closely discounted protect in Bentley Suite of St. Regis Istanbul
$41,000+
No
2017
China (by strategy of Turkey)
Free enterprise class tickets for two on round time out from Original York to China
$16,000+
No
2018
Hungary (by strategy of Turkey)
Free crimson meat up to enterprise class for two on round time out from Original York to Hungary
$12,000+
No
2019
Turkey
Free crimson meat up to enterprise class for one on flight from Original York to Turkey; free protect at Cosmopolitan Suite of St. Regis Istanbul; free meals, transportation, and entertainment in Istanbul
$9,000+
No
2021
Turkey (solicited and licensed nevertheless then canceled)
Free crimson meat up to enterprise class for two on round time out from Original York to Turkey; free or steeply discounted luxurious lodge and resort stays, transportation, entertainment, and meals
$21,000+
No
2021
Ghana (by strategy of Turkey)
Free crimson meat up to enterprise class for two on round time out from Original York to Ghana; free meal and transportation all over Istanbul layover
$12,000+
No
David and Philip Banks, Pearson and Wright have had their phones and electronics seized by the feds, who’re probing whether or not they’ve had any hand in steering city contracts to support themselves or relatives, sources have told The Post.
None had been accused of wrongdoing.
Mayor Eric Adams is greeted as he visits the Turkish Consulate Overall building after it became once vandalized in Original York, May per chance well simply 22, 2023. AP
One Adams insider talked about the Turkish probe, which incorporates free trek back and forth and campaign donations, “stems partly from awful administration choices.” GC Pictures
One Adams insider talked about the Turkish probe, which incorporates free trek back and forth and campaign donations, “stems partly from awful administration choices,” alongside with assigning unqualified of us to jobs that require “no longer ideal ethical scrupulousness, nevertheless indecent consideration to detail.”
In particular concerning became once the different to tap Briana Suggs, Adams’ used intern with shut ties to his inner circle, to back as key guide and fundraiser for his 2021 mayoral campaign.
Private investigator near me: Take care of up to this level with the Original York Post’s coverage of Mayor Eric Adams’ indictment
“I don’t mediate they had been wide awake sufficient about the strict felony guidelines surrounding campaign finance, in particular when it comes to international nationals, and they prioritized raising money over making definite that it became once all above board,” the insider talked about.
Adams, 64, started as a transit cop and rose by procedure of the ranks of the NYPD to the issue Senate, to Brooklyn borough president, to City Hall. He made historical previous this week because the first sitting mayor to be criminally indicted.
One concerning different became once utilizing Briana Suggs, Adams’ used intern to back as a key guide and fundraiser for his 2021 mayoral campaign, document says.
Adams’ private skill to race ethical quagmires for the duration of his time as a cop and his political occupation can also have at final caught up to him once he arrived at City Hall, in accordance with Democratic sources.
“As his circle has grown . . . as his vitality has grown, his headcount has grown, the corruption has gotten worse,” a Democratic councilmember talked about.
Throughout his time in Albany from 2007 to 2013, Adams became once accused by the issue inspector regular in 2010 of accepting substantial campaign donations from of us associated with bidders for a on line casino contract at Aqueduct Racetrack.
David Banks, Adams, and First Deputy Mayor Sheena Wright (L-R), launched incoming Faculties Chancellor Melissa Ramos all over a news convention on the Bronx Faculty for Law, Govt and Justice on September 25, 2024. James Keivom
The case became once referred to federal prosecutors, nevertheless he became once by no formula charged
And after Adams became once elected Brooklyn beep in 2013, the city Division of Investigation stumbled on a fundraising nonprofit he created to finance his station of enterprise’s pet projects, One Brooklyn, violated city guidelines.
“He got right here inner an inch of being indicted a pair of cases and has apparently gotten away with it, so clearly he felt he also can continue to catch away with it,” one primitive Democratic insider talked about. “Nonetheless it is probably going you’ll’t outrun the Southern District of Original York.”
